FitSNPs: highly differentially expressed genes are more likely to have variants associated with disease

Genes associated with polymorphic variants predicting lung function are differentially expressed during human lung development

BACKGROUND Recent meta-analyses of genome-wide association studies have identified single nucleotide polymorphisms (SNPs) within/near 54 genes associated with lung function measures. Current understanding of the contribution of these genes to human lung development is limited. We set out to further define i) the expression profile of these genes during human lung development using a unique set ...

maternal grandmothers with advanced age reproduction are more likely to have down syndrome grandchildren

down syndrome (ds), trisomy 21, is the most common chromosomal syndrome that affects one in 600-800 live births. the advanced maternal age is the only well known risk factor to cause ds. our study revealed that many young mothers produced ds children than advanced age mothers in india. a total of 150 suspected ds cases were investigated cytogenetically. randomly selected 200 healthy families in...

Faster Evolving Primate Genes Are More Likely to Duplicate

An attractive and long-standing hypothesis regarding the evolution of genes after duplication posits that the duplication event creates new evolutionary possibilities by releasing a copy of the gene from constraint. Apparent support was found in numerous analyses, particularly, the observation of higher rates of evolution in duplicated as compared with singleton genes. Could it, instead, be tha...

Salmonella enterica highly expressed genes are disease specific.

During in vitro broth culture, bacterial gene expression is typically dominated by highly expressed factors involved in protein biosynthesis, maturation, and folding, but it is unclear if this also applies to conditions in natural environments. Here, we used a promoter trap strategy with an unstable green fluorescent protein reporter that can be detected in infected mouse tissues to identify 21...

Are angry men more likely to develop cardiovascular disease?